Positive Oral Estrogen Steroids Powder Exemestane Aromasin for
Breast Cancer Treatment
1) Product name: Exemestane
2 ) Alias: Aromasin ; Exemestan;Exemestane
3 ) CAS No: 107868-30-4
4 ) MF: C20H24O2
5 ) MW: 296.40
6 ) Puity: 99%
7 ) Appearance: White or Almost White Crystalline Powder
8 ) Usage: Developed to help fight breast cancer, Aromasin is one
of the most powerful estrogen suppressing compounds.
a. Aromasin is one of the most powerful estrogen suppressing
b. Aromasin is one of the best compounds to lower the aromatizing
effect of steroids.
c . Aromasin is available for body builders taking anabolic
d . Aromasin is also known as Exemestane.
e. It acts by blocking the enzyme aromatase, subsequently blocking
the production of estrogen.
f. Aromasin is also a kind of .antineoplastic (hormonal) raw
Exemestane,(trade name Aromasin) is a drug used to treat breast
cancer. It is a member of the class of drugs known as aromatase
inhibitors. Some breast cancers require estrogen to grow. Those
cancers have estrogen receptors, and are called ER-positive. They
may also be called estrogen-responsive, hormonally-responsive, or
hormone-receptor-positive. Aromatase is an enzyme that synthesizes
estrogen. Aromatase inhibitors block the synthesis of estrogen.
This lowers the estrogen level, and slows the growth of cancers.
Exemestane is an oral steroidal aromatase inhibitor that is used in
ER-positive breast cancer in addition to surgery and/or radiation
in post-menopausal women.
The main source of estrogen is the ovaries in premenopausal women,
while in post-menopausal women most of the body's estrogen is
produced via the conversion of androgens into estrogen by the
aromatase enzyme in the peripheral tissues (i.e. adipose tissue
like that of the breast) and a number of sites in the brain.
Estrogen is produced locally via the actions of the aromatase
enzyme in these peripheral tissues where it acts locally. Any
circulating estrogen in post-menopausal women as well as men is the
result of estrogen escaping local metabolism and entering the
The estrogen suppression rate for exemestane varies from 35% for
estradiol (E2) to 70% for estrone (E1)
This medication is used to treat certain types of breast cancer
(such as hormone-receptor-positive breast cancer) in women after
menopause. Exemestane is also used to help prevent the cancer from
returning. Some breast cancers are made to grow faster by a natural
hormone called estrogen. Exemestane decreases the amount of
estrogen the body makes and helps to slow or reverse the growth of
these breast cancers.
Exemestane is an irreversible, steroidal aromatase inactivator,
structurally related to the natural substrate androstenedione. It
acts as a false substrate for the aromatase enzyme, and is
processed to an intermediate that binds irreversibly to the active
site of the enzyme causing its inactivation, an effect also known
as "suicide inhibition." By being structurally similar to enzyme
targets, Exemestane permanently binds to the enzymes, preventing
them from converting androgen into estrogen.
Exemestane is taken in tablet form once a day. Patients can
experience side effects like nausea, anxiety, shortness of breath,
abdominal pain, bone pain, and chest pain. Side effects vary widely
between patients and patients should report the side effects they
experience to their doctors, as some may be indicators of dangerous
complications. Shortness of breath and chest pain in particular are
causes for concern in patients taking exemestane.
|Description||: White Crystalline Powder||White Powder|
|Assay(by HPLC)||: 98.0~102.0%||98.64%|
|Melting Point||: 191~195°C||193.5~195.0°C|
|Loss On Drying||: 0.5%max||0.19%|
|Specific Rotation||: +288°~ +298°||+290.2°|
|Residue On Ignition||: 0.1%max||0.03%|
|Related Substances||: Total:1.5%max||<1.3%|
|Residue Solvents||: 0.2%max||0.10%|
|Heavy Metals||: 20PPm max||<10PPm|
|Conclusion||The specification conform with enterprise standard.|
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